Pharmacology Quick Reference: Anticoagulants, Anemia, and Antiarrhythmics

Posted by on Feb 14, 2025 in Pharmacy | 0 comments

Anticoagulants

Unfractionated Heparin (UFH)

  • Mechanism: Antithrombin III, Xa/IIa
  • Dosage:
    • Loading dose & continuous infusion: 80 units/kg load, 18 units/kg/h infusion
    • Prophylaxis: 5000 units subcutaneously
  • Contraindications: HIT (Heparin-Induced Thrombocytopenia), hypersensitivity, thrombocytopenia, active bleeding or risk of bleeding
  • Monitoring: aPTT (activated Partial Thromboplastin Time), baseline and every 6 hours until 2x therapeutic level; goal 1.5-2.5x baseline
  • Reversal Agent: Protamine sulfate

Low

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