Cellular Mechanisms in Cancer: Pathways, Genes, and Therapies
Cellular Pathways
This section details key cellular signaling pathways and processes fundamental to cell function and often dysregulated in cancer.
MAPK Pathway
The Mitogen-Activated Protein Kinase (MAPK) pathway promotes cell growth, proliferation, differentiation, survival, and resistance to apoptosis. Its activation cascade is as follows:
- Raf activates Ras.
- Ras activates MEK (MKK).
- MEK activates ERK.
- ERK activates RSK.
- RSK (in the nucleus) activates CREB.
Caspases and Apoptosis
Caspases are enzymes that
Read MoreOptimizing Work Environments: Lighting and Thermal Comfort
Workplace Environmental Factors
Lighting in the Workplace
Light is electromagnetic radiation to which the human eye is sensitive. It is an environmental factor of great importance in the workplace because appropriate conditions ensure tasks are performed effectively and safely. The following types of lighting are recognized:
- Natural Lighting: This is the most desirable due to its advantages, being a free source and carrying the implied health benefits associated with sun exposure.
- Artificial Lighting:
Cellular Life: Nutrition, Energy, and Plant Processes
Essential Life Functions and Cellular Basis
Three Vital Functions for Organisms
Living organisms perform three vital functions:
- Nutrition: Obtaining the matter and energy necessary to live.
- Interaction/Relationship: Taking in information from the environment and responding to it for survival.
- Reproduction: Giving rise to new living beings, similar to those from which they originated.
The Cell: Fundamental Unit of Life
The cell is the structural and functional unit of all living beings, capable of performing
Read MoreBiological Classification Systems: Understanding Life’s Organization
The Science of Taxonomy and Biological Classification
As you have discovered, living things are put into groups according to their characteristics. This is called classification. The characteristics used to classify living things determine the groups they are placed into. The chosen characteristics form a classification system.
About half a million different kinds of living things have been discovered so far, with more organisms added to this list each year. Scientists use a classification system
Read MoreFungi Explained: Biology, Reproduction, Key Types, Food & Health Effects
Fungal Characteristics
Fungi are eukaryotic organisms classified within the Kingdom Fungi, encompassing yeasts, molds, and mushrooms. While once grouped with plants, fungi possess unique characteristics that led to their classification in a distinct kingdom. The primary distinctions from plants are their heterotrophic nature and cell walls not constructed from cellulose.
Fungal Reproduction
Sexual Reproduction in Fungi
Fungal sexual reproduction relies on the compatibility between hyphae, either from
Read MoreAdvanced Biotechnology: Stem Cells & Cloning
Stem Cell & Cloning Applications
Stem Cell Therapy Applications
Stem cells frequently offer the possibility of replacing damaged cells and tissues. They may be used to treat various conditions, including:
- Parkinson’s disease
- Alzheimer’s disease
- Spinal cord injuries
- Brain injuries
- Heart injuries
- Regenerating the pancreas in diabetics
- Regenerating epithelial cells, etc.
Understanding Gene Activation & Inhibition
Understanding the mechanisms of activation and inhibition of genes could lead to a cure for
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