Male Reproductive System: Anatomy and Function
Male Reproductive System
Testicles
- Gonads
- Located in the scrotum
- Exo-endocrine gland
A-Exocrine gland:
- Seminiferous tubules spermatogenesis ®
- Genital tract and testis is Extratesticular
B-Endocrine Gland:
- Interstitial cells secrete testosterone in a web of tissue between the seminiferous tubules
Role of body temperature:
- Normal sperm production: 35°C
- To accomplish this, the testicles are away from your body, encased scrotum
Pampiniform venous plexus:
- Surrounding each testicular artery and help maintain low temperature in the scrotum
General organization:
1 – External Coverage:
- Tunica albuginea: thick capsule of dense connective tissue
- Tunica vaginalis: mesothelial serous sac, anterior and lateral surface covers testicular
- The tunica albuginea is thickened on the back and form: mediastinum testis
2 – inside cover:
- Tissue of the tunica albuginea into the parenchyma extensions start around 250 ® testicular lobules
- Each is occupied by 1-4 seminiferous tubules
- They are in a network of loose connective tissue, vessels, and nerves
Seminiferous Tubules:
A-Frame:
- Sinusoidal Appearance
- Fornix lead ®straight tubules rete testis ® ® ® epididymal efferent ducts
Its walls: 3 coats
Three layers:
1 – Tunic own:
- Thin layer of tissue fibroelastic with several layers of fibroblasts
- The innermost layer of the tunica propria myoid cells (characteristic of a smooth muscle myocyte)
Contractile movements of the tubules
2 – Basement membrane:
- Separate the tunica propria of the seminiferous epithelium and germ
3 – germinal epithelium:
- Two cell lines that give rise: sperm
1. Spermatogonia:
- Small cell
- Nucleus with irregular chromatin distribution
- It is the only one present before puberty
Spermatogonia:
- Divide:
A-similar to stem cell
B-cell to stop dividing and growing to form: spermatocytes 2
Intratesticular ducts:
A-tubules straight:
- Home epithelium similar to that of the seminiferous tubules
- Then the cells are lost until only a simple cuboidal epithelium
B-Red Testicular
- Anastomosing tubules in the mediastinum testis
- Upholstery: simple cuboidal epithelium or simple flat
C-tubules Efferent:
- From 10 to 20 tubules
- Measuring 4-6 mm
- Its walls: smooth muscle
- Upholstery: cubic epithelium ciliated columnar
- Epithelium is capable of absorbing fluid secreted by seminiferous tubules
- Penetrate the head region of the epididymis and flow: epididymal duct
Extratesticular or excretory ducts
A-Epididymis:
- Length: 4-6 meters
- This well run over on itself
- Pseudostratified cylindrical epithelium at the apical: microvilli
B-Vas Deferens:
- Thick-walled straight tube
- Light: close
- Thick wall: smooth muscle
- Its mucosa has many folds
- Mucosa upholstered: pseudostratified ciliated columnar epithelium
- Lamina propria: connective tissue rich in elastic fibers
- Muscle layer: highly developed smooth muscle
- 2 longitudinal layers: internal and external, 1 circular middle layer
- Adventitia: connective tissue
- In the terminal portion before entering the prostate, it expands and forms: Blister
- In the terminal region of the ampulla, seminal vesicle empties
Ejaculatory duct:
- Short tube upholstery: pseudostratified columnar epithelium
- You lose the muscle layer
Urethra:
Genitourinary Tube
A-seminal vesicle:
- They are 2 each: tube 15 cm long coiled upon itself
- Mucosa: epithelium lined by simple cuboidal or low cylindrical pseudostratified
- This mucosa is highly folded
- Cells: rich granules are secretory proteins, fructose, citrate, inositol, prostaglandins
- Lamina propria: rich in elastic fibers
- Muscle: smooth muscle
- Inner layer of circular fibers
- Outer layer of longitudinal fibers
- Its secretion builds up inside and is eliminated in the ejaculation by contracting the smooth muscle fibers
B-Prostate Gland:
- It surrounds the urethra below its origin bladder
- Composite: 30 – 50 tubulosaccular glands, branched flow: prostatic urethra
Produce: prostatic fluid and store it inside.
- Upholstered: simple cuboidal epithelium or pseudostratified cylindrical
- Secretor: protein
- The epithelium on the inside has a large number of lysosomes, with intense activity: acid phosphatase
- Important determinant of cancer cases
- Three areas:
1-Central: pseudostratified epithelium, glandular volume occupies 25%
2 – Peripheral: main site in the development of malignant tumors
3 – Transition: small, site of origin of benign
- At the peripheral level:
- Fibroelastic tissue capsule
- Smooth muscle contracted during ejaculation
- This capsule form walls.
Bulbourethral glands or cowpers
- Peers
- Tubulosaccular glands located behind the membranous urethra
- Cells: mucous type
- Partitions divide: smooth and skeletal muscle
Mucosa: simple cuboidal epithelium.
Penis
Organization:
- Three bodies of erectile tissue, spongy tissue surrounded by + urethra
- Externally wrapped by thin skin
- Two mass numbers: corpus cavernosum
- Ventral mass: corpus cavernosum of the urethra
- The 2 bodies of the penis are surrounded: tunica albuginea of the penis
- TA forms a strong membrane of dense connective tissue that is inserted between 2 corpus cavernosum
- This wall is not continuous septa
- The corpus cavernosum of the urethra: is enclosed in a thin
connective tissue
Erectile tissue:
- It forms an irregular network around each body
- This comprises: fibrous tissue forming trabeculae and that also contains smooth muscle fibers
Blood supply: S.
- It depends on the functional status:
A-State flaccid: dorsal peripheral arteries, immersed in the loose connective tissue ® arterial blood supply
Drainage of venous blood:
- Two dorsal veins: superficial and deep
In flaccid state, the AV shunts between arteries deep and superficial veins are open.
B-erect state:
- AV shunts are closed
- Innervation:
- Parasympathetic stimulation: erection
- The sympathetic contribution: ejaculation
Foreskin:
- Contains: connective tissue, skin, smooth muscle
- Features retractable
- Regarding its inner fold and the area of skin over the glans note: sebaceous glands
Immune System
- Reticular connective tissue where most of the cells represent lymphocytes
Primary (LB-LT)
- Lymphoid Organs
Secondary (lymph nodes, spleen, MALT)
RXS occur in these immune.
- Lymphoid organs: primary and secondary
- Clusters of lymphoid tissue in non-lymphoid organs
- Lymphocytes scattered in TC and TE
- Lymphocytes, stem cells, plasma cells, macrophages, dendritic cells, granular leukocytes, and mast cells
- Mean insensitivity to infection
Congenital skin, stomach acid
- 2 types: phagocytosis and inflammation
Acquired antibodies
- Specific defensive Rx Immune Response
- Tolerance: no rx immune to the components of the body
- Memory
TYPES OF IMMUNITY
Two Types:
- Mobile: made by T lymphocytes that eliminate the sustuncias directly or by activation of phagocytes
- Humoral: using antibodies (globulins) produced by plasma cells circulating formed from B lymphocytes.
Lymphatic Organs
TIMO
- Primary lymphoid organs
- Site of maturation of LT
- It is located in the anterior mediastinum
- It weighs 50 grams and regresses at puberty
- Composed by 2 lobes
- It originates from ectodermal and endodermal epithelium branchial groove 3 in the 6 weeks
- It is surrounded by CT capsule septa toward issuing corticomedullary boundary divides the lobes into lobules
- The lobules are polyhedral and measure 0.5-2mm in diameter
- It has a darker area and rich in cells called the cortex and a lighter and less marrow cell called
- It has a loose stroma composed of epithelial reticular cells form a network among which are lymphocytes, macrophages, and dendritic cells
- Reticular cell has abundant eosinophilic cytoplasm and large clear oval nuclei with 1 or 2 nucleoli, and star-shaped extensions interdigitating with each other
- Cortical reticular cells originate from the endoderm and the medullary and subcapsular reticular (premium) from the ectoderm
- The bone has Hassall corpuscles are round or oval structures composed of concentric layers of flattened epithelial cells similar to onion rings with a size of 20-100 microns and increases with age
- Are most abundant in bone marrow macrophages
- Dendritic cells are found mostly in the corticomedullary boundary
- At the heart have long extensions in contact with lymphocytes and, like the lattice involved in the maturation of lymphocytes
- As involution progresses appears larger amount of adipose tissue replacing the parenchyma
LYMPH NODES
- Secondary lymphoid organs brought flattened kidney-shaped in the course of lymphatic pathways
- Their size varies from a few mm to 2 cm
- Surrounded by dense CT capsule that sends projections to the interior trabecular
- Presents a hilum on one edge where the capsule is thicker
- It has several afferent lymphatic vessels
- Presents a single efferent vessel present in the porta
- It is divided into a central area called the medulla and a cortex
- In the cortex are formed follicles (nodules)
- The stroma is composed of fibers and reticular cells
- Interdigitating dendritic cells are located in the deep crust and in the hair follicle of the cortex (the latter have no antigen)
- Subcapsular sinus between the cortex and capsule
- Cortical sinuses along the trabeculae
- Medullary sinuses medullary cords separated
SPLEEN
- Secondary lymphoid organ located in abdominal CSI
- Weight 150-200 g and measuring 4x8x12 cm
- Brought into the bloodstream
- Surrounded by dense CT capsule with few smooth muscle fibers from which trabeculae extend into the
- It has only efferent lymphatic pathways
- It originates from the dorsal mesogastrium mesenchyme during the 5 wk
- Serves as erythropoietic organ during the second trimester of pregnancy
- Hilar region presents oriented stomach
- The marginal zone is the area constraint between the red and white pulp
- The parenchyma is called pulp
Red: irregular thin-walled vessels
(Sinusoidal) splenic cords separated by
- Pulp
White: oval or rounded areas
gray or white, 1 mm
diameter composed of lymphoid tissue
diffuse or follicular (Malpighian corpuscle)
TONSILS
- Clusters of lymphoid tissue that are located in the path of lymph vessels.
- There are three:
- Palatine
- Pharyngeal
Lingual.
- Oropharynx
- Lymphoid tissue is organized into nodules covered by a surface epithelium: oropharynx, which invaginates: 10 to 20 times to form the crypts
- Featuring tej thickening posteriorly. disorders: which separates them from deep levels
Pharyngeal:
- Lymphoid tissue: lymph covered by respiratory epithelium, with absence of crypts.
Tongue:
- Numerous
- Located at the base of the tongue
- Lymphoid tissue: lymph
- His mucosal crypts invaginates and forms
OJO
- Photosensitive bodies
- Refractory structures: cornea, lens
- Visual information is transmitted: the optic nerve to brain
- Eyeball:
- A-fibrous tunic
- B-Vascular
- C-Nerve
A-fibrous tunic:
- Outer:
1 – Sclera (whites)
2 – Cornea.
1-Sclera:
- White coat
- Opaque
- Covers 5 / 6 following
2 – Cornea:
- Clear and colorless
- Cover 1 / 6 previous
Sclera:
- Poor blood vessel
- Composite:
- Fibrous connective tissue, collagen I and elastic fiber networks
- In deeper regions: melanocytes
Cornea:
- Anterior
- Transparent
- Avascular
- Very innervated
- Slightly thicker than the sclera
Histological layers composed 5.
1 – corneal epithelium:
- Continuation of the conjunctiva
- Keratinized stratified squamous epithelium
- 5 to 7 layers of cells in the anterior surface of the cornea
- More superficial cells have microvilli ® zonulae occludens
- The remaining cells are joined by desmosomes
- Free nerve endings innervated
- More superficial cells have microvilli ® zonulae occludens
- The remaining cells are joined by desmosomes
- Free nerve endings innervated
- Union: scleral-corneal: limbo ® a groove whose spaces are lined by endothelial trabecular meshwork
- This network gives rise: canal of Schlemm: site through which aqueous humor leaves the anterior chamber into the venous system
4 – Descemet membrane:
- Basal
- Gross
- At birth and in young people: thin
- Aging thick
5 – corneal endothelium:
- Inner surface: horny
- Synthesize: Descemet membrane proteins
- Reabsorbed sodium bomb excess fluid in the stroma
Tunic B-vascular:
- Tunica media [uvea]
- Three components:
- Choroid
- Ciliary body
- Iris
A-Choroid:
- Pigmented
- Very vascular
- Loosely attached to the fibrous
- Composes: TCL, collagen fibers, elastic vessels
- Black: melanocyte
- Inner choriocapillaris layer: provides the nutrients to the retina
- Bruch Membrane: elastic fiber network
- Separate: choroid retina
B-ciliary body:
- Extension of the choroid
- Ciliary processes: short projections of the body towards the lens
- Composite: TCL, elastic fibers, blood vessels and many melanocytes
- Inner surface is covered: pigmented layer: epithelium.
- In this body are fenestrated capillaries
- The ciliary processes that send fibers are inserted into the lens capsule: suspensory ligament of lens
- Find: non-pigmented epithelium: ultrafiltrate produced plasma: aqueous humor
- The main volume of the ciliary body is composed of: 2 bundles of smooth muscle: ciliary muscle
A beam is inserted into the sclera, the other along the inner wall of the body.
C-Iris:
- Most anterior extension of the choroid
- It covers most of the lens, except at the pupil
- Posterior surface is smooth: Covered in layers of the ciliary body
- Epithelial cells facing the stroma of the iris have extensions: m pupil dilator: myoepithelial nature
- The melanocytes of the iris blocking passage of light and give the eye color
Lens:
- Transparent
- Flexible
- Biconvex
- Composed of epithelial cells
- Consists of 3 parts:
1 – Capsule: basal lamina, collagen IV and glycoproteins that cover epithelial cells
2 – subcapsular epithelium: single-level anterior surface, single layer of cuboidal cells: gap-junction
3 – lens fibers: about 2000 cells long, they lose their nucleus and are filled with protein.
Vitreous Body: (vitreous humor)
- Refractive Gel
- Transparent
- Fill the cavity of the eye behind the lens
- 90% water, few electrolytes, collagen fibers and hyaluronic acid
C-nerve Tunic (Retina):
- Photoreceptor cells: rods and cones
- Differentiated cells of the brain are
- Optical Disk
- Optical Disk:
- It is located in the posterior wall of the eye
- At the exit of the optic nerve
- Absence: cone-rod
- It is insensitive to light: blind spot
- A + / – 2mm: macula lutea: pigment area
- In the middle of it we have an oval depression: central fovea
- Peak visual acuity: single cones
- As we move away from her, the rods and cones decrease increase
Retina: 10-layer composite:
1 – pigment epithelium:
- Cubic to cylindrical
- Nucleus basalis
- Posted in Bruch’s membrane (between the choroid and pigment cells)
- Desmosomes, occludents, acceding form: blood-retinal barrier
- Have microvilli on their apices surrounding rods and cones
- Cells have many melanin granules synthesized by them
- Rer, A. Well-developed Golgi
- Features: absorb light, phagocytosis and esterified derivatives of Vit. A in REL
2 – Layer Rods and Cones:
- Their apical portions: specialized dendrites
- Their bases: neighboring cell synapse
100 to 120 million rods and 6 million cones.
Canes:
- Light to activate light: black and white
- They are long cells have:
- 1 outer and inner segment
- Nuclear region
Synaptic region.
Cones:
- Are active in bright light
- Produce greater visual acuity
It is the vision of colors.
- The rod-like structure
- There are 3 types of cones: each has a different variety of rhodopsin:
- Sensitivity: red, green, blue
- The rod-like structure
4 – outer nuclear layer:
- Mainly occupied by nuclei of cone-rod
5 – outer plexiform layer:
- Axodendríticas synapses between photoreceptor cells and other neurons
6 – inner nuclear layer:
- Nuclei formed by bipolar cells, amacrine, horizontal and Muller
7 – inner plexiform layer:
- Synapse axodendríticas
- Among the bipolar cell axons and dendrites of ganglion cells
8 – ganglion cell layer:
- Multipolar cell bodies of neurons
- Hyperpolarization activated rod and cone cells ®
- It generates an action potential to be amacrine and horizontal cells, and finally to the brain
9 – optic nerve fiber layer:
- Unmyelinated axons of ganglion cells
10 – internal limiting membrane:
- Cell basal lamina muller
ANNEXES TO THE EYE
A-Conjunctiva:
- Stratified epithelium
- Goblet cells resting on a basal lamina and a proper TCL
- Two types: palpebral and bulbar
B-Lids:
- Skin folds
C-Lacrimal Apparatus:
- Lacrimal gland
- Serosa tubuloalveolar
- Resembling the parotid
- The tear fluid: sterile
- High% water and lysozyme
- Help to keep moist and hydrated to the sclera and cornea
- Travel through a system of lacrimal canaliculi
- Lined by stratified squamous epithelium
- Lacrimal sac: dilated upper portion of the nasolacrimal duct
- This upholstery: pseudostratified ciliated columnar epithelium
- The follow below: Nasolacrimal
- It has the same epithelium
Ear
Vestibulo cochlear
- Body: hearing and balance
- It is divided into 3 parts:
1 – External ear
2 – Middle ear: tympanic cavity
3 – Inner ear
The sound wave is received by the outer ear ? reaches the tympanic membrane mechanical vibrations ?
- In middle ear ossicles tympanic cavity ?
- The cacidad amplifies the vibrations and transfer them to the inner ear
- This is a labyrinth full of perilymph which is responsible for hearing and balance conservation
Ear
- External
- Average
- Internal
External:
- Pinna
- Ear canal
Media:
- Tympanic cavity
- Tympanic membrane
- Eustachian tube
- Mastoid antrum
- Mastoid cells
- Tympanic cavity (hammer, anvil, stirrup, stirrup muscle and muscle from the hammer)
Internal:
- Maze (in the petrous bone)
- External Labyrinth
- Membranous labyrinth
- Endolymph
- Perilymph
- The bony labyrinth communicates with the tympanic cavity by ½ of the oval window
- Oval window:
- It closes with the base of the stapes (transmitting the vibrations of the ossicles to the perilymph)
- Also with the cochlear window which closes with the secondary tympanic membrane
EXTERNAL EAR
Ear elastic cartilage plate, covered by skin
External auditory meatus:
- Superficial: elastic cartilage that is continuous with the ear
- In its 2 / 3 is replaced by the internal temporal bone: bra
- Covered: skin, hair, Gland tympanic membrane:
- Outer surface: epidermis thin
- Inner surface: squamous epithelium simple cubic
- Between the two surfaces are elastic collagen fibers, fibroblasts
- Sound waves are received by ½ of it (vibrate)
- ulas modified sebaceous sudorápadas: ceruminous: cerumen
MIDDLE EAR
- Space filled with air, which is located in the petrous temporal bone
- Covering: simple squamous epithelium
- In the area around the auditory tube: ciliated pseudostratified
- Lamina propria was strongly attached to the bony wall of the trunk and contains no glands,
- At the level of the cartilaginous portion of the lamina propria it contains mucous glands with goblet cells and lymphoid tissue
- Swallowing or yawning trunk make the hole to open and equalize air pressure between the tympanic cavity, auditory meatus
Oval and round window:
- They are located in the medial wall of tympanic cavity
- Connect the middle ear cavity to the inner ear
Are membranes.
Ossicles:
- Hammer, anvil, stirrup
- Articulated by synovial lined by simple squamous epithelium
- Hammer: tympanic membrane inserted
- Stirrup: inserted into the oval window
- Yunque: interposed between the two previous
INNER EAR
Composite:
- Bony labyrinth: cavity within the petrous temporal bone
- Membranous labyrinth: suspended within the bony labyrinth
Bony labyrinth:
- Three components:
- Semicircular canals
- Lobby
- Cochlea
- Investing: endosteum
- Separated by membranous labyrinth perilymphatic space (the full perilymph)
Its central region: vestibule.
- Semicircular canals: three superior, posterior and lateral
- Lobby: it is central
- In its side wall contains the oval window and round or cochlear
- Houses: special regions: the utricle and saccule
- Snail-shaped bony structure of spiral
- At the central level ? ? modiolus central bony spine
Membranous labyrinth:
- Composed of epithelium derived from ectoderm
- This epithelium invades the temporal bone and form 2 sacks: utricle, and saccule
- In endolymph circulates around the maze (composition similar to the SCI)
Membranous labyrinth:
- There are thin bands of tissue attached to the endosteum of the bony labyrinth
- These bands passing through the endolymph and inserted into the membranous labyrinth
- Important to carry blood vessels that nourish the lining of the membranous labyrinth
Membranous labyrinth:
- Saccule and utricle:
- It is connected by duct utrículosacular
- From each tiny tubes out: endolymphatic duct
Saccule walls – utricle:
- External: vascular tissue layer
- Internal: simple squamous epithelium simple cuboidal
- Specialized regions act as receptors that perceive the orientation of the head relative to gravity and acceleration: macula utricle saccule and macula
Saccule walls – utricle:
- The epithelium of recipient regions: light and dark cells
- Clear cells: microvilli, cytoplasm, ribosomes and few mitochondria
- Dark cells: abundant vesicles, lipid droplets, many mitochondria, are thought to control the composition of endolymph
- Macules: composed of 2 types of neuroepithelial cells:
- Hair cells type I, II
- Supporting cells
- Hair cells are innervated by auditory nerve fibers
- Each of them has: 50-100 stereocilia in a row
Type I hair cells:
- Cytoplasm little RER, golgi supranuclear and many small vesicles
- Each esterocilio is a microvillus with many actin filaments
Type II hair cells:
- Similar to Type I
- More cylindrical
- Cytoplasm, Golgi apparatus and more larger vesicles
Supporting cells of the macula:
- Interposed between both hair cells
- They have microvilli
Developed Golgi.
- The stereocilia of hair cells are covered by a dense glycoprotein ? gelatinous otolithic membrane
- The surface of this membrane region has tiny crystals of calcium carbonate otoliths
Semicircular canals:
- Below are the membranous labyrinth
- Each duct is dilated at the lateral end ? blisters
- The blisters contain ampullary crests: special reception areas
- Each peak level of his lip has a free surface covered: sensory epithelium
- Formed: neuroepithelial hair cells and supporting cells
Cochlear duct and organ of Corti:
Cochlear duct:
- Receptor organ that is housed in the cochlea
- Contains:
- Scala media
- Vestibular membrane
- Basilar membrane
- Scala vestibuli
- Located above the vestibular membrane
- Full perilymph
- Scala tympani
- Find below the basilar membrane
- Filled with perilymph
- Vestibular membrane:
- Composed of 2 layers of simple squamous epithelium separated by a basal lamina
- Basilar membrane:
- Holds the organ of Corti
- Composed of 2 parts: curved and dentate
The arch provides support to the organ of Corti.
- The side wall covered by a pseudostratified epithelium
- Stria vascularis contained inside an intraepithelial plexus capillaries
- Composes 3 types of cells:
- Basal
- Intermediate
Marginal.
ORGAN OF CORTI.
- Receiving organ specialized in hearing
- It lies on the basilar membrane
- It is composed of neuroepithelial hair cells and supporting cells
- These cells are pillar cells, phalangeal, edge and those of Hensen
Neuroepithelial cells of the organ or Corti hairy:
- Specialize in the transduction of the impulses to the organ of hearing
- According to their locations are called hairy: internal and external
- This system is located in the vestibular inner ear
- Consisting of utricle, saccule and semicircular canals
- The linear movement of the head moves the endolymph, and alters the location of the otoliths
Vestibular function:
- Produce movements in the stereocilia of hair cells
- These are translated into action potentials that are driven by acoustic nerve synapses to the mite and to the brain
- The circular movements: they are perceived by receptors at the level of bony semicircular canals
Vestibular function:
- The information related to linear and circular movements of the head is recognized by receptors of the inner ear and are transmitted to the brain via the auditory nerve
- Within the brain to produce the interpretation and balance adjustments occur through the activation of muscle groups responsible for the position